If you spend any time taking sculpture classes in zbrush etc. And view the vfx development of on screen characters both human and animal, the underlying bone structure and musculature is always developed first. Poser characters have always been like a plastic shell with no underlying structure. The unrealistic joints and folds like at shoulders and under knees as an example, are testament to this. It seems to me that characters should be developed that reproduce all the relevant muscles and bone structure and that posing is accomplished by actuating every relevant muscle to achieve that pose. The skin should then react to that underling muscle. Once the pose is achieved the underlying structure could be deleted.