I use Clip Studio Paint.
Your image above is great, but very far from what I'm after. I don't know anything about Comic Life 3, but if I had to guess I'd say you had a Firefly base render, some basic adjustments in post for contrast, lightness, etc, and then some edge-finding and noise filters in various combinations. Am I close? Rather than use that kind of automation, I'd just go ahead and re-draw the picture. It would give me a lot more flexibility and cut down on the overhead for props and clothes and stuff. Time consuming, but probably not much worse than having to get the render just right, and then do all the photo manipulation kinds of postwork. I was (still am, actually) hoping that I could get Poser to do something close enough to the finished style I'm after that all the pre-production work would cut out most of the post-production work, but I'm not seeing that so far...