It all depends on what you're starting with, and what you want to end up with, and who your intended audience is going to be.

If...

1. You start with -- the sort of super-clean studio-model photos that such naff Photoshop filters and actions always use for their promos.

2. You end up with -- a sort of ersatz airbrushed 'made from a photo' Photoshopped look, perhaps even with kind-of half-decent ink lines.

3. And the audience is -- people who have never once looked inside a good comic-book in their lives.

Then... the audience will nod politely, even as regular comics readers cringe and fling the thing against the nearest wall.

If on the other hand...

1. You start with -- carefully de-grunged, toon re-textured, and Comic Book filtered and inked characters in Poser 11, rendered out as separate layers ready for recombination in Photoshop.

2. You end up with -- after much workflow-crafting, a repeatable and appealing result that 99.9% of comic-book readers can't tell came from 3D.

3. And the audience is -- not the super-critical 0.1% of graphics uber-professionals who will smell a rat.

Then... you can probably make a saleable comic that people will want to read and perhaps even cherish.

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Learn the Secrets of Poser 11 and Line-art Filters.