I have my content broken down into separate runtimes, 99 at present, which are all held on a USB remote SSD so that I can move the same content between different computers if required. Way back when I started I think I had two runtimes the Poser runtime and the downloads but I have had my present setup since Poser 6 with it growing each year as I split any runtime that becomes too large. For example I used to have a runtime for buildings which included anything associated with buildings both both internal and external, this is now broken down into smaller runtimes called cities, buildings, cottages and cabins, and rooms. I use P3dO explorer to do the runtime moves when splitting.

I have had any problems with any re-installs of Poser and if I was really worried I would unplug the SSD before any install and just link the runtimes again if required. One advantages of storing the content in this way is that I can do incremental backup but also regular clones of the SSD

 

 

I use Poser 13 on Windows 11 - For Scene set up I use a Geekcom A5 -  Ryzen 9 5900HX, with 64 gig ram and 3 TB  storage, mini PC with final rendering done on normal sized desktop using an AMD Ryzen Threadipper 1950X CPU, Corsair Hydro H100i CPU cooler, 3XS EVGA GTX 1080i SC with 11g Ram, 4 X 16gig Corsair DDR4 Ram and a Corsair RM 100 PSU .   The desktop is in a remote location with rendering done via Queue Manager which gives me a clearer desktop and quieter computer room.