12 ½ years later [xp-pen's bot sure went digging!], my answer is about the same as it was then. I'm on my second Wacom now. Used primarily for texture painting and sculpting [which didn't exist when this thread was started], I do sometimes use it for working with UV maps, particularly stitching up/aligning large selections of points, pretty much everything else 3D is traditional mouse for me.

I'm left handed, and the home position/shortcuts for every program are all left hand based, having learned and used them for a long while before getting a digitizer, they're just "natural" for me at this point, so I'm quicker/more efficient with a mouse for most stuff if shortcuts are going to be involved. Couldn't live without it for the more "expressive" aspects of 3D tho.

Core i7 950@3.02GHz | 12GB Corsair Dominator Ram@1600mHz | 2GB Geforce GTX 660

Lightwave | Blender | Marmoset | GIMP | Krita