I had Poser Pro 11.3 running on 10.10. I never upgraded my (now retired) 4,1 Mac Pro past that.

Specs: 4,1 2x 6 cores @ 2.93Ghz, 96Gb of Ram, RX 560 (4gb), 2x250gb SSD - Raid 0, 4x2TB in dual Raid 0 (1 - iTunes Library, 1 - 3d Assets).

It has shuffled off this mortal coil, and was replaced with a Ryzen system.

Realistically, at some point, you have to let go of old tech and software.

And I would tell every mac user that has an extensive 3d workflow - you need to plan to transition away from Mac - Timmy doesn't love you.