If disk-size, rather than Library-clutter, is the problem then one way is to run the free WinDirStat on your runtimes. It will give you a visual display in which you can easily see the largest files. You can then decide what to do with each big item. Is it connected with content you're ever likely to use? If not, then you delete it or archive it. You can get yourself several Gb of space this way, from a large 20-year runtime. Especially useful for more recent DAZ Studio content, where recent hair meshes and textures can be stupidly large.

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Learn the Secrets of Poser 11 and Line-art Filters.