I have found that with importation of Genesis 3 and 8 figures into Poser there is a bug with the right hand in particular. You can create a hand preset for her right hand and apply it and it will work great...come back later and use it again and her thumb goes stupid with it. The bug, as best as I can pin it down, comes down to Poser swapping the data with the hand's skeleton (I guess). There is a sort of fix I've found. Set whatever pose or preset you want on her LEFT hand, then use the FIGURE > SYMMETRY > LEFT ARM TO RIGHT ARM option. There will be a popup asking DO YOU WANT TO COPY THE JOINT ZONE'S SETUP? Select YES. This will copy the hand pose over to the problematic right arm and also correct it's thumb rotation. Again, though Poser will inevitably screw it up again later, so this becomes a constant corrective process. I discovered this "fix" some years back when one of my Victoria 4.0 figures got her thumb screwed up because I applied a RIGHT hand morph to a LEFT hand so it sort of inverted the thumb twisting. So I remembered the fix later when Gen3 did it...and now Gen8 as well. I hope this helps some. Not sure if it's exactly the issue you're having but sure seems similar.