F-Secure is blocking sqlite_x64release.dll. That's why the interface won't stay set. That information is stored in a SQL data table. Without sqlite there is no data table. It's a miracle Poser launches at all missing such an important dll.The library uses data tables too.

This is a problem with F-Secure, not Poser. Especially if you've told it to exclude the files and it continues to false on it. That's a deal-breaker bug in F-Secure.

I've submitted the file in question to several multi-engine scanner sites. The only AV that giving false positives on sqlite_x64release.dll is F-Secure. Here's the results from jotti.org. Note only F-Secure is falling.