Yes, if something causes a GPU render to fail, for any reason, Poser will need to be restarted to reset the GPU. Is one of those "Sawing off the branch you're standing on things" Poser can't reset the GPU while it's using it.

Anybody with CUDA errors. Please open a ticket at https://support.posersoftware.com/ and attache the scene as a zip created by the built in scene collection File > Export > Save for sharing ... command. If the scene is too big we'll provide you a way to send in larger attachments.