Downside (depending on your aesthetic aims) is that, unless you do a bit of fussing and post, the line weights can be a bit dead if you're looking for a more brush line or nib type line weight. Or you can just make friends with the style as it is and go with that like I tend to do. The lines tend to have a more rapidograph style. 

Also rendering very large helps with the aliasing of the line work out of preview, the above images were rendered not terribly large for the intent to illustrate a forum point in demo rather than to be "artworks" for art's sake. Literal illustrations. You'll get better lines larger, then you can downsize. Doesn't increase the render time or resources any.

Sketch renderer in my case has been useful to add interesting line/texture effects as a composite layer in post, as in here in conjunction with Firefly IBL/AO...