From what I've been able to check with Poser12: it uses as a base path this setting:

And from there, it'll create some sub folders in which it'll drop some files. Some of them seem to stay after filled (PoserTextureCache, cefcache, etc..) whereas others are empties once the render is over (PoserFFRencerCache)

Be sure that some valid path is set there. In my case, it's located on an SSD drive, as are all Poser's Runtimes, and executable directories, for example.

Oh and be sure that no f..cking anti-virus isn't interfering there

PhYl.

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