you have reinstalled the program, but have you applied the last service pack to that installation?  I have version 5-13 on my computer and only 8 won't run due to I.E. being removed.  you need to run the latest patch which would be 10.0.5.28925.  Without that patch Poser will not run.  There was a Windows update that disabled certain features that 10 requires.  This patch is the only one that has ever been issued to a prior Poser version when the newer version was out.  The patch itself is about 95MB in size.

Poser 5, 6, 7, 8, Poser Pro 9 (2012), 10 (2014), 11, 12, 13