you can remove the Layers manually, but for the setup created on all materials of V4 sure the faster way to reload a new V4. The Layer Pz2 file is set to remove all other textures making a clean blank V4 to start up with. If you load it two times on the same model , well you will get a duplicate layer making a stronger effect on the Vascularity :) or mess it up ... trying to load two different ones might even bring out some surprising results ; did not try it my self .....