Poser 10 and its pro counterpart Poser Pro 2014 are freestanding applications and don't require online activation.  However, there are remaining issues with Adobe Flash and Adobe AIR.  Some of those issues were solved with the service releases, I believe there are 4 of those in existence.  I had Poser Pro 2014 installed on a computer that transitioned from Win 7 to Win 10 and it still performed without any problems.