I see your scene is called "Untitled" - are you working without saving your scene beforehand? 

Poser is known for failing simulation calculations on unsaved files, it tends to get confused on where to save temporary files needed by the simulation. Save first before having it calculate the simulation.

(sorry if this went twice - I sent the comment, and then it didn't appear for me, so I typed it out again.)

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Feel free to call me Ohki!

Poser Pro 11, Poser 12 and Poser 13, Windows 10, Superfly junkie. My units are milimeters.

Persephone (the computer): AMD Ryzen 9 5900x, RTX 3070 GPU, 96gb ram.