Lighting can be tricky depending on the scene.  The fewer lights, the better so you may concentrate on the main aspects and mood of the scene.

In your case, use the Inverse Square attenuation and low intensity on some of your lights.  Background lighting spillover can be very distracting and take away from you point of interest.  You want to contribute to the eeriness.  Deep shadows surrounding your characters will help enhance the mood.  Spotlights, area lights, and point lights will help in this department.

The most important thing is to make sure the material shaders on your characters are not emitting ambient glow.  This is the reason I rework all my object shaders to be compatible to Superfly rendering.  I want all my materials to behave as realistically as possible.  

In your case, concentrate on the characters and foreground, and perform minimal changes to background objects.  You want good render for a comic page without going overboard for absolute details.