Well, most software should work, and if not, there are upgrades out there. Personally, I think you should be beyotch slapped for running ME in the first place (silly boy, lol, j/k). Personally, I'm running xp on a 380 with 128 ram, which is "bare bones" and it fricking JUICES! None of the major programs should have any glitches, and if they do, there is almost certainly an update on their respected websites.