I've been working on the big momma (The Grudge) for a long time Syyd. The file is a little over 500 megs in size. Only now, just after I decided it was finished, does it refuse to open. Fortuantately, I already burned it to cd. Me thinks its just my lackluster system deciding its had enough! Anyways, I'm fairly certain I have as many, if not more layers going than you got (you didn't say how many, and I can't check cause it wont open anymore!), but photoshop 6.0 opened it for me day in and day out for about 5 months. Not only do I have about 40-50 layers going, but they're all in 600ppi as well. just saw it, a 150 layers!!!?????! Shyte yo, that's a lot... Anyways, I have photoshop take up 75% of my available ram on startup, and if I know I ain't doing ANYTHING else, I boost it up to 90%, then restart the program. Point being, you likely have a mondo killer system going, so maybe it was just some random freak accident. God bless LZW compression though for final prints eh?