It's taken some trial and error, but I've adopted a system of multiple runtime folders, each dedicated to a particular project. I keep all but the active one in a folder outside the application, then I switch off as needed. Beyond that, for my everyday RunTime, I have a folder within Textures called "New textures" and within that I have a series of sub folders for, first, Mike, Vicky, et al, then within those, clothing and body textures for each, with subcategories as needed. It keeps everything very clean.