If you are using a program like the ones I mentioned, then you don't need to compress anything prior to editing. You simply load the image sequence and the editor will play the sequence as though it were a video, allowing you to make edits like you would with any piece of video. This is subject to the limits of your hardware of course, as are all things. You will want a fast hard drive, fast processor, lots of RAM, and a good graphics card. If the hardware is having trouble with the uncompressed image sequence, then you can create low res proxies (like .jpg stills or low res movie files) to use in the editing and then swap back to the uncompressed images when you are ready to do your final output. If your video editor doesn't support image sequences, then you will need something to turn the stills into a video file before loading it into the editor. If you have to do this, be very careful with the compression that you use, because once you have finished your editing and output your final video file, you may end up with double compression artifacts due to the images having been compressed twice instead of once.