Runs fine on my AMDs. A lot of it has to do with the quality of the motherboard and it's compatability with the RAM on it. I also use two Pentium computers. Bothe My Pentium AMD computers run the same with Poser4. In the past I have had Pentium and AMD combinations that bothe had issues though. It's always been the cheap motherboards like my BCM or my FIC ones that had problems. So far as long as I have stuck with the top RAM and motherboards brands rated at Anandtech.com I've been alright.