The advantages of NTFS are many. Better security, not only for accessing files, but better at not losing data due to corruption. It is also a faster file system than FAT32. I take the opposite view than some, I believe that NTFS is the way to go unless you have a specific reason to go with FAT32. If you have a large hard drive, you might want to use a combination NTFS/FAT32 drive. Format the system partition with NTFS, and format the other with FAT32. I do not know what will happen as far as PBooost goes. It may still not work, even if you put Poser and PBooost on the FAT32 partition because of the presence of NTFS on the system partition.