I have XP home, but have used it in ME, and never had a problem, the only thing that sometimes happens is after I tell Vue to import a file, whether it be an .obj, .3ds or .pz3, from time to time it says can't open, as soon as I close that box, I try again and it opens it.....some kind of hiccup I think in Vue or XP in the interupt system. Sharen