How about animating weird color changes of the eyes, or maybe the fingernails turn yellow as a bolt of yellow electricity shoots from them. Or the pattern on a body suit ala the movie Tron. Bruises or diseases appear on a skin. You could animate the chest texture so it looks like the skin is becoming transparent and a heart is beating within. Animate a talking magic mirror. You can also do wierd stuff. Bobasaur (I am 7 of 12)

Before they made me they broke the mold!
http://home.roadrunner.com/~kflach/