I always save and keep a "master" image in Photoshop format, to maintain layers and channels - it's crucial for re-editing later on. When I need to share the file in any way, I save a copy to a minimally compressed jpg. Personally, I DO see a quality loss, even in first generation jpgs. Most often, the compression artifacts appear in solid colors, near a border with a different color. Text also doesn't compress very well. Anything that's had a "noise" filter run on it won't compress very highly and loses detail. I usually have to ask others if they see the degradation. They usually don't. I guess I'm just very critical about my images. I think that comes from my photography background. I've been known to re-print a photograph in the darkroom a dozen times until I'm happy with it. Similarly, when working "digitally" in Photoshop, I'll output several different resolutions and compressions and scrutinize each one to no end... Maybe I should seek help? -sk