This will be a quick answer because I'm moving my office from one room to another. I'll swear that all the cables have self installed easy pose and I have dust bunnies forming herds and trying to make a break for the door :)

Save as a PZ3 and your simulation should get saved also. There will be a DYN file also created that you have to keep in the same directory. (Still looking for it's reference in the CR2). If you save the dynamic clothing as a smart prop it will save the cloth groups. I set some in the Hareem costume so you should have seen those. I think it saves the cloth dial settings, but would need to check.

Yes you will need to do a new simulation if you change the pose.

OK gotta go ... one dust bunny is getting ugly.