You're welcome. :) I really like Poser 5, so it's tough hearing about people who can't run it. :( Definitely try turning off the anti-virus software. By nature, anti-virus software is pretty intrusive. I've heard of it causing problems with software before. Even if Poser does work without it running, I don't know if keeping the virus software off is a good permanent solution for you, but it would at least pinpoint the conflict. Firewall software could also potentially be a problem. You're running all the potential problem apps on your system! ;) I have no idea about USB devices. :) Maybe someone else would know about that... And good luck again! Auralia