I do not believe that a removable drive would be 100% useful. If the OS (Operating System) and applications are on the removable drive, and the drive is pulled, any other drives would not be usable; since they need an OS to access them. On the other hand, if the OS is on a fixed drive, and Poser and the applications are on a removeable drive, then you still have the system files from the installed applications within the OS folder (ie, c:windows) when that drive is removed. If there is a serious enough issue, a removable drive may not solve anything, but introduce other issues.