Thanks a lot to all of you for your help. After trying out several things for little details

on the basic mesh I have found a way which is working best for me: The basic meshes

will be made with Hexagon and the wrinkels and little details I will make with

Zbrush. The results are much more better in Zbrush as in Hexagon.

Hi Phil, thanks for your reply. What do you think are the advantages of Truespace?

I am using Hexagon at the moment, the handling is easy, and the first steps of creating meshes

are also done fix. But I have problems with making details with Hexagon, wrinkles with the

displacement tool are looking really odd and not naturally.

I tried out ZBrush (a demo version of it), because saw a video of making wrinkles and that was

looking awesome. But after trying out ZBrush, oh my god, the handling is horrible.

Yes Hexagon would be great for you. The Software has an area for Second Lifes prim also :-)