I'm thinking Anime Studio and say Okhams Z-Flatten python script or Toon Shaders would be an awesome combo!!!  Get the beauty of 3D characters that will end up moving in a nice traditional 2D style!!  All animations I've done with toon shaders  to give the  traditional  2D style still  ended up looking distinctly 3D from the movement, animation and  3D lighting in my experience.  Gonna be interested in seeing what can be done with this!!!  Here's a Z-Flattened Aiko...  gonna try taking it into PhotoShop to slice up the parts then into Anime Studio!!  Wish me luck!!!

G

The GR00VY GH0ULIE!

You are pure, you are snow
We are the useless sluts that they mould
Rock n roll is our epiphany
Culture, alienation, boredom and despair