I've started to lose a lot of work this way, usually on my larger Poser scenes with more than 1 figure.
I save my work and shut down Poser in the normal way.  When I fire up my pc next time and reload there's nothing there - the main document window doesn't open and all I have is grey screen and the rest of the Poser interface.
I can only assume the Poser gremlins have messed up my pz3 while I was asleep.
Anyone else get this?