I have multiple runtimes, all on a dedicated external drive. I only have a few attached to Poser 13, but it's really struggling with them. It takes a really long time to load anything. I get frequent error messages about access being denied. I don't have this problem with other programs.

I do occasionally get that error message with Poser 11, but trying again fixes it, very quickly. Poser 13 takes so long to load anything I'm finding it unusable. I've gone back to Poser 11 for now.