I am having an issue with a figure I am making. I am trying to rig a robot I made, and when I leave the Setup Room everything works fine, the joints all work and everything, but any save files I make be they in the library or as a scene file don't save properly. When I open the file it has no bones and the color on the model goes all messed up. I have tried re-rigging it, but the same thing keeps happening. I usually don't have this problem when I rig things, but it has popped up a couple of times in the past. Why does it do this with some of my models and not others? The robot isn't symetrical, I have compression turned off, and I am using Poser 6 if that matters. Has anyone else seen this before? It is driving me insane! Any help would be greatly appreciated.

I've had Poser crash during saves after setting up figures. It's very frustrating. I've also had corrupt saves. That destroys your work as well. 

My advice is to save versions of your figure every time you do anything significant in the Setup process. This will prevent the sort of failures that eradicate every bit of your work and you can fall back to a previous version when the inevitable malfunction occurs. 

The Setup room is flaky indeed. I usually only create and name the bones in the Setup room, and switch back to the Pose room for joint adjustments.

Thanks for the responses. I managed to get it to work out after all. The only thing I could think of that I was doing wrong is when I was creating a new bone and the previous one was moving to line up that when I hit undo to return it to its normal position I screwed it up. I didn't touch the undo this time and it worked. 
I too do as little work in the setup room as possible. Is it actually possible to save your progress in the setup room without leaving it? I have just been saving the unfinished rig in the library and then reapplying it to the base mesh in order to save in increments.